Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monomethyl Fumarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 known ✓ | Q14145 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Monomethyl Fumarate SCHEMBL15826620 | 0.84 | HCAR2 (0.50) | HCAR2NFE2L2KEAP1ALDH1A1KDM4E | |
| Fumaric Acid SCHEMBL7463657 | 0.84 | TSHR (0.43) | HCAR2ALDH1A1KDM4EMAPTTDP1 | |
| Maleic Acid SCHEMBL30024098 | 0.84 | TSHR (0.43) | HCAR2ALDH1A1KDM4EMAPTTDP1 | |
| Fumaric Acid SCHEMBL6625237 | 0.84 | TSHR (0.43) | HCAR2ALDH1A1KDM4EMAPTTDP1 | |
| Maleic Acid SCHEMBL6625236 | 0.84 | TSHR (0.43) | HCAR2ALDH1A1KDM4EMAPTTDP1 | |
| Fumaric Acid SCHEMBL7463662 | 0.84 | TSHR (0.43) | HCAR2ALDH1A1KDM4EMAPTTDP1 | |
| Monomethyl Fumarate SCHEMBL23247866 | 0.78 | HCAR2 (0.94) | HCAR2NFE2L2KEAP1ALDH1A1KDM4E | |
| Monomethyl Fumarate SCHEMBL5526015 | 0.78 | HCAR2 (0.94) | HCAR2NFE2L2KEAP1ALDH1A1KDM4E | |
| Monomethyl Fumarate SCHEMBL9320264 | 0.78 | HCAR2 (0.94) | HCAR2NFE2L2KEAP1ALDH1A1KDM4E | |
| Monomethyl Fumarate SCHEMBL60132 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3243511-B1 | PRODRUGS OF MONOMETHYLFUMARATE (MMF) | RATIOPHARM GMBH (DE) | 2019-03-20 | — | — | EP | disclosed |
| US-9868690-B2 | Prodrugs of monomethyl fumarate (MMF) | RATIOPHARM GMBH (DE) | 2018-01-16 | — | — | US | disclosed |
| EP-3243511-A1 | PRODRUGS OF MONOMETHYLFUMARATE (MMF) | ratiopharm GmbH (DE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2934507-B1 | PRODRUGS OF MONOMETHYL FUMARATE (MMF) | RATIOPHARM GMBH (DE) | 2017-05-31 | — | — | EP | disclosed |
| EP-2934507-A2 | PRODRUGS OF MONOMETHYL FUMARATE (MMF) | ratiopharm GmbH (DE) | 2015-10-28 | — | — | EP | disclosed |
| US-20150299103-A1 | PRODRUGS OF MONOMETHYL FUMARATE (MMF) | RATIOPHARM GMBH (DE) | 2015-10-22 | — | — | US | disclosed |
| WO-2014096425-A2 | PRODRUGS OF MONOMETHYL FUMARATE (MMF) | RATIOPHARM GMBH (DE) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150299103-A1 | PRODRUGS OF MONOMETHYL FUMARATE (MMF) | TPMT, FH, FAH | KEAP1 1886/4885HCAR2 350/4885NFE2L2 775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.