Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.54 |
| ▸ | PDE4A | P27815 | 4/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | NEK2 | P51955 | 1/20 | 0.53 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.53 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15815661 | 0.77 | MET (0.57) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL15815987 | 0.69 | CHEK1 (0.70) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL2765797 | 0.68 | SLC16A3 (0.46) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL15815327 | 0.68 | PDE4B (0.64) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL15815000 | 0.67 | PDE4B (0.80) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL15815964 | 0.67 | PDE4A (0.63) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL15815451 | 0.67 | PDE4A (0.50) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL2764392 | 0.67 | PDE4A (0.47) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL25225919 | 0.67 | PDE4A (0.58) | PDE4BPDE4APDE4CPDE4DCHEK1 | |
| SCHEMBL15815321 | 0.67 | CHEK1 (0.66) | PDE4BPDE4APDE4CPDE4DCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935253-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | Zenith Epigenetics Corp. (CA) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014096965-A2 | NOVEL HETEROCYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS | RVX THERAPEUTICS INC. (CA) | 2014-06-26 | — | — | WO | disclosed |