Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 9/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.43 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12026997 | 0.85 | POLB (0.52) | FFAR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12026544 | 0.84 | POLB (0.53) | FFAR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12026809 | 0.79 | CFTR (0.55) | GLSCFTR | |
| SCHEMBL12026796 | 0.77 | GLS (0.54) | GLSMEN1KMT2AUSP2ALDH1A1 | |
| SCHEMBL12026551 | 0.73 | POLB (0.59) | FFAR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12026546 | 0.73 | FFAR2 (0.58) | FFAR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2198160 | 0.72 | GLS (0.79) | GLSDGAT1NPC1RAB9A | |
| SCHEMBL12026491 | 0.72 | POLB (0.60) | FFAR2MEN1KMT2ANPC1RAB9A | |
| SCHEMBL12026543 | 0.71 | SCD (0.46) | FFAR2MEN1KMT2ACFTRTSHR | |
| SCHEMBL12027009 | 0.69 | POLB (0.56) | MEN1KMT2ANPC1RAB9ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759335-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-24 | — | — | US | disclosed |
| US-8759335-B2 | Modulators of ATP-binding cassette transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-06-24 | — | — | US | disclosed |