Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 6/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 4/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | ATR | Q13535 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19313495 | 0.80 | PDE2A (0.34) | APP | |
| SCHEMBL6936507 | 0.80 | P2RX7 (0.34) | APP | |
| SCHEMBL19313511 | 0.77 | TLR7 (0.34) | KCNH2HRH3 | |
| SCHEMBL12141414 | 0.77 | SYK (0.47) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL1532884 | 0.77 | ESR1 (0.50) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL15986833 | 0.76 | CYP1A2 (0.32) | APPCYP3A4 | |
| SCHEMBL1022641 | 0.76 | — | — | |
| SCHEMBL24667797 | 0.75 | PIK3CD (0.40) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL12141412 | 0.75 | S1PR4 (0.47) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL19432655 | 0.75 | MBOAT4 (0.43) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015010078-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2015010049-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2015-01-22 | — | — | WO | disclosed |
| WO-2014172044-A1 | SUBSTITUTED BENZENE COMPOUNDS | Epizyme, Inc. (US) | 2014-10-23 | — | — | WO | disclosed |
| WO-2014144747-A1 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014100665-A1 | 1,4-PYRIDONE BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |