Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15833974 | 1.00 | LMNA (0.40) | LMNAGAAHPGDMAPTTSHR | |
| SCHEMBL15833948 | 0.85 | LMNA (0.38) | LMNAHPGDMAPTTSHRSMN1; SMN2 | |
| SCHEMBL15833946 | 0.85 | LMNA (0.38) | LMNAHPGDMAPTTSHRSMN1; SMN2 | |
| SCHEMBL8538369 | 0.85 | TSHR (0.39) | LMNAHPGDMAPTTSHRHSD17B10 | |
| SCHEMBL8587563 | 0.84 | GAA (0.38) | LMNAGAAHPGDMAPTTSHR | |
| SCHEMBL15833991 | 0.83 | L3MBTL1 (0.44) | LMNAGAAHPGDMAPTTSHR | |
| SCHEMBL15835857 | 0.83 | L3MBTL1 (0.44) | LMNAGAAHPGDMAPTTSHR | |
| SCHEMBL15834000 | 0.82 | LMNA (0.37) | LMNAHPGDMAPTPRMT5WDR77 | |
| SCHEMBL12732931 | 0.79 | LMNA (0.45) | LMNAHPGDTSHRHSD17B10SMN1; SMN2 | |
| SCHEMBL23866537 | 0.79 | MEN1 (0.40) | LMNAGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100764-A2 | METHODS OF INHIBITING PRMT5 | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014100730-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |