Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | KDM5C | P41229 | 2/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070497 | 0.81 | — | — | |
| SCHEMBL3660629 | 0.77 | LMNA (0.63) | LMNAPOLBTDP1MCL1KDM4E | |
| SCHEMBL1297846 | 0.75 | — | — | |
| SCHEMBL15834111 | 0.75 | LMNA (0.38) | LMNAPOLB | |
| Hydrochloric Acid SCHEMBL3355086 | 0.73 | LMNA (0.48) | LMNAPOLBTDP1MCL1KDM4E | |
| SCHEMBL8163507 | 0.70 | KDM4E (0.59) | LMNAPOLBMCL1KDM4EKDM5C | |
| SCHEMBL23735526 | 0.69 | LMNA (0.55) | LMNAPOLBTDP1MCL1KDM4E | |
| SCHEMBL487785 | 0.69 | LMNA (0.48) | LMNAPOLBMCL1KDM4ECTSD | |
| SCHEMBL6683840 | 0.69 | LMNA (0.48) | LMNAPOLBMCL1KDM4EALDH1A1 | |
| SCHEMBL4831329 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014100734-A1 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |