Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8806728 | 0.87 | GPR119 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL3243612 | 0.87 | GPR119 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL376575 | 0.87 | GPR119 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL8064199 | 0.87 | GPR119 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL9386815 | 0.87 | GPR119 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL27730319 | 0.83 | CHRM2 (0.36) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL20789245 | 0.83 | HSD17B10 (0.40) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL19287265 | 0.82 | TSHR (0.42) | GPR119CHRM2CHRM1CHRM3TSHR | |
| SCHEMBL25436769 | 0.81 | NR1H2 (0.43) | GPR119CHRM2CHRM1CHRM3HSD11B1 | |
| SCHEMBL19898506 | 0.81 | NR1H2 (0.43) | GPR119CHRM2CHRM1CHRM3HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9643955-B2 | 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-05-09 | — | — | US | disclosed |
| US-9643955-B2 | 2-pyridyloxy-3-nitrile-4-substituted orexin receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150322041-A1 | 2-PYRIDYLOXY-4-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | disclosed |
| US-20150322041-A1 | 2-PYRIDYLOXY-4-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2015-11-12 | — | — | US | disclosed |
| WO-2014099698-A1 | 2-PYRIDYLOXY-3-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322041-A1 | 2-PYRIDYLOXY-4-NITRILE-4-SUBSTITUTED OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NTSR2 | GPR119 63/4885CHRM2 414/4885CHRM1 379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.