Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19898506 | 1.00 | NR1H2 (0.43) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL2252585 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL699280 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL489252 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL5058842 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL5691732 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL1154972 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL7805563 | 0.88 | MMP2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL20789245 | 0.87 | HSD17B10 (0.40) | NR1H2NR1H3CYP1A2POLBCYP3A4 | |
| SCHEMBL27730319 | 0.82 | CHRM2 (0.36) | NR1H2NR1H3CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |