Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | BCL9 | O00512 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15826329 | 0.99 | ROCK2 (0.52) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838882 | 0.92 | ROCK2 (0.61) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL15819957 | 0.91 | ROCK2 (0.60) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838798 | 0.89 | ROCK2 (0.52) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838794 | 0.89 | ROCK2 (0.49) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL15826223 | 0.89 | ROCK2 (0.51) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838855 | 0.88 | KCNQ3 (0.43) | ROCK2SIRT2LMNABCL9CTNNB1 | |
| Hydrochloric Acid SCHEMBL15819600 | 0.88 | ROCK2 (0.49) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838797 | 0.88 | ROCK2 (0.55) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL15838891 | 0.87 | ROCK2 (0.56) | ROCK2SIRT2LMNAPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890117-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY | 2017-02-23 | — | — | US | disclosed |
| US-9371277-B2 | Benzamide compounds and related methods of use | NORTHWESTERN UNIVERSITY (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | NORTHWESTERN UNIVERSITY (US) | 2014-08-21 | — | — | US | disclosed |
| WO-2014100833-A1 | BENZAMIDE COMPOUNDS AND RELATED METHODS OF USE | NORTHWESTERN UNIVERSITY (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050926-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | ROCK2 1718/4885SIRT2 1/4885LMNA 1970/4885 |
| US-20140234939-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | ROCK2 1718/4885SIRT2 1/4885LMNA 1970/4885 |
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | ROCK2 1718/4885SIRT2 1/4885LMNA 1970/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.