Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17288086 | 0.94 | EZH2 (0.57) | EZH2 | |
| SCHEMBL15839149 | 0.94 | EZH2 (0.57) | EZH2 | |
| SCHEMBL15839134 | 0.94 | EZH2 (0.54) | EZH2 | |
| SCHEMBL15839127 | 0.93 | EZH2 (0.53) | EZH2 | |
| SCHEMBL15839003 | 0.90 | EZH2 (0.56) | EZH2 | |
| SCHEMBL17288092 | 0.90 | EZH2 (0.56) | EZH2 | |
| SCHEMBL15839172 | 0.89 | EZH2 (0.55) | EZH2 | |
| SCHEMBL15839055 | 0.88 | EZH2 (0.54) | EZH2 | |
| SCHEMBL15839166 | 0.87 | EZH2 (0.59) | EZH2 | |
| SCHEMBL15839158 | 0.84 | EZH2 (0.53) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935214-B1 | 1,4-PYRIDONE COMPOUNDS | EPIZYME INC (US) | 2019-02-20 | — | — | EP | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2015-12-03 | — | — | US | disclosed |
| WO-2014100646-A1 | 1,4-PYRIDONE COMPOUNDS | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150344427-A1 | 1,4-PYRIDONE COMPOUNDS | PDXK, PNPO, PLPBP | EZH2 3465/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.