Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12686632 | 1.00 | ALDH1A1 (0.62) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL18923939 | 0.96 | TSHR (0.62) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL16589858 | 0.94 | TSHR (0.69) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL17369037 | 0.91 | TSHR (0.61) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL12733524 | 0.91 | TSHR (0.76) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL12673953 | 0.90 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL20151931 | 0.90 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL11921661 | 0.90 | ALDH1A1 (0.55) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL13165265 | 0.88 | TSHR (0.49) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 | |
| SCHEMBL13641016 | 0.88 | TSHR (0.49) | ALDH1A1TSHRHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765130-B2 | Antagonistic DR3 ligands | NOVO NORDISK A/S (DK) | 2014-07-01 | — | — | US | disclosed |
| US-8765130-B2 | Antagonistic DR3 ligands | NOVO NORDISK A/S (DK) | 2014-07-01 | — | — | US | disclosed |