Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | SOS1 | Q07889 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | KRAS | P01116 | 2/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 6/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5423541 | 0.89 | SOS1 (0.46) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL1263834 | 0.89 | SOS1 (0.46) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL12382084 | 0.86 | SOS1 (0.40) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL2795192 | 0.80 | SYK (0.43) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL4975328 | 0.75 | AKT1 (0.42) | AKT1PIK3CAMTORGRM5PDE4D | |
| SCHEMBL30880752 | 0.75 | AKT1 (0.42) | AKT1PIK3CAMTORGRM5PDE4D | |
| SCHEMBL21940472 | 0.71 | SOS1 (0.41) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL1905561 | 0.70 | CYP3A4 (0.43) | AKT1PIK3CAMTORSOS1CYP3A4 | |
| SCHEMBL18518448 | 0.70 | AKT1 (0.43) | AKT1PIK3CAMTORSOS1GRM5 | |
| SCHEMBL18518444 | 0.70 | AKT1 (0.43) | AKT1PIK3CAMTORSOS1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-B1 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC (US) | 2014-07-02 | — | — | EP | disclosed |