Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 8/20 | 0.46 |
| ▸ | CDK2 | P24941 | 8/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.38 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046637 | 0.91 | CCNA2 (0.46) | CCNA2CDK2CCNA1ALDH1A1RAD52 | |
| SCHEMBL15850652 | 0.90 | CCNA2 (0.45) | CCNA2CDK2CCNA1ALDH1A1RAD52 | |
| SCHEMBL15850622 | 0.89 | CCNA2 (0.55) | CCNA2CDK2CCNA1ALDH1A1RAD52 | |
| SCHEMBL1199362 | 0.87 | PDE7A (0.42) | CCNA2CDK2CCNA1RAD52IKBKB | |
| SCHEMBL12046636 | 0.86 | CCNA2 (0.40) | CCNA2CDK2CCNA1RAD52IKBKB | |
| SCHEMBL12060226 | 0.85 | KDM4E (0.39) | CCNA2CDK2CCNA1ALDH1A1ACHE | |
| SCHEMBL12046621 | 0.84 | CCNA2 (0.51) | CCNA2CDK2CCNA1ALDH1A1RAD52 | |
| SCHEMBL12046654 | 0.82 | KMT2A (0.37) | CCNA2CDK2CCNA1ALDH1A1ACHE | |
| SCHEMBL12046640 | 0.82 | ALDH1A1 (0.52) | CCNA2CDK2CCNA1ALDH1A1RAD52 | |
| SCHEMBL1199219 | 0.79 | PDE7A (0.42) | CCNA2CDK2CCNA1RAD52IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |