Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15855482 | 0.94 | NPC1 (0.37) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL15855478 | 0.84 | CASP1 (0.34) | NPC1RAB9ACRHBPCRHR2 | |
| SCHEMBL15855479 | 0.79 | CASP1 (0.35) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL6921433 | 0.75 | RAB9A (0.38) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL15855484 | 0.75 | — | — | |
| SCHEMBL15818082 | 0.73 | CACNA2D1 (0.38) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL14240256 | 0.72 | CACNA2D1 (0.39) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL15855483 | 0.72 | NPC1 (0.37) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL6920730 | 0.71 | NPC1 (0.33) | NPC1RAB9ACRHBPCRHR2L3MBTL1 | |
| SCHEMBL6920480 | 0.71 | NPC1 (0.44) | NPC1RAB9ACRHBPCRHR2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772301-B2 | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof | SUNOVION PHARMACEUTICALS, INC. (US) | 2014-07-08 | — | — | US | disclosed |