SCHEMBL15856480

SCHEMBL15856480

Cc1ccc(C#N)c(-c2cccc3ccccc23)c1

nearest known ligand 0.48

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MCL1 Q07820 1/20 0.47
MAOA P21397 1/20 0.47
MAOB P27338 1/20 0.47
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
XDH P47989 1/20 0.44
FNTA P49354 3/20 0.43
FNTB P49356 3/20 0.43
PGGT1B P53609 2/20 0.43
PIM1 P11309 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15856497 0.87 GRM2 (0.52) MCL1MAOAMAOBCA1CA2
SCHEMBL29038987 0.84 CYP1A2 (0.49) MCL1MAOAMAOBCA1CA2
SCHEMBL21899538 0.83 TSHR (0.48) PIM1
SCHEMBL28203557 0.81 CA1 (0.60) MCL1CA1CA2XDHPIM1
SCHEMBL7575965 0.81 MCL1 (0.47) MCL1CA1CA2FNTAFNTB
SCHEMBL15853136 0.80 FNTA (0.50) MCL1CA1CA2FNTAFNTB
SCHEMBL20561064 0.79 MCL1 (0.58) MCL1CA1CA2XDHPIM1
SCHEMBL31236642 0.79 MCL1 (0.58) MCL1CA1CA2XDHPIM1
SCHEMBL2353695 0.79 CA1 (0.53) MCL1CA1CA2XDHPIM1
SCHEMBL17954822 0.79 IMPDH2 (0.37) FNTAFNTB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140183468-A1 PYRENE-BASED COMPOUND AND ORGANIC LIGHT-EMITTING DIODE COMPRISING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2014-07-03 US disclosed