Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 15/20 | 0.70 |
| ▸ | DRD3 | P35462 | 14/20 | 0.70 |
| ▸ | ACHE | P22303 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL605223 | 1.00 | HTR2A (0.70) | HTR2ADRD3ACHEDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL607420 | 0.99 | HTR2A (0.69) | HTR2ADRD3ACHEDRD2SLC6A4 | |
| Hydrochloric Acid SCHEMBL607419 | 0.99 | HTR2A (0.69) | HTR2ADRD3ACHEDRD2SLC6A4 | |
| SCHEMBL604085 | 0.92 | ACHE (0.71) | HTR2ADRD3ACHEDRD2SLC6A4 | |
| SCHEMBL3249919 | 0.92 | ACHE (0.71) | HTR2ADRD3ACHEDRD2SLC6A4 | |
| SCHEMBL604710 | 0.88 | HTR2A (0.74) | HTR2ADRD3ACHE | |
| SCHEMBL15859551 | 0.87 | HTR2A (0.73) | HTR2ADRD3 | |
| SCHEMBL607331 | 0.87 | HTR2A (0.73) | HTR2ADRD3 | |
| SCHEMBL605222 | 0.87 | HTR2A (0.73) | HTR2ADRD3 | |
| SCHEMBL15859540 | 0.87 | HTR2A (0.69) | HTR2ADRD3ACHEHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183245-B1 | DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2014-07-09 | — | — | EP | claimed |