SCHEMBL3249919

SCHEMBL3249919

N[C@H]1CC[C@H](CCN2CCC(c3noc4cc(F)ccc34)CC2)CC1

nearest known ligand 0.71

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.71
HTR2A P28223 13/20 0.70
DRD3 P35462 13/20 0.70
DRD2 P14416 1/20 0.69
SLC6A4 P31645 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL604085 1.00 ACHE (0.71) ACHEHTR2ADRD3DRD2SLC6A4
SCHEMBL15859552 0.92 HTR2A (0.70) ACHEHTR2ADRD3DRD2SLC6A4
SCHEMBL605223 0.92 HTR2A (0.70) ACHEHTR2ADRD3DRD2SLC6A4
Hydrochloric Acid SCHEMBL607419 0.91 HTR2A (0.69) ACHEHTR2ADRD3DRD2SLC6A4
Hydrochloric Acid SCHEMBL607420 0.91 HTR2A (0.69) ACHEHTR2ADRD3DRD2SLC6A4
SCHEMBL28504239 0.89 ACHE (0.71) ACHEHTR2ADRD3DRD2SLC6A4
SCHEMBL605707 0.87 HTR2A (0.70) HTR2ADRD3
SCHEMBL3249824 0.87 HTR2A (0.70) HTR2ADRD3
SCHEMBL604059 0.87 HTR2A (0.73) ACHEHTR2ADRD3DRD2SLC6A4
SCHEMBL606612 0.87 HTR2A (0.73) ACHEHTR2ADRD3DRD2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2183245-B1 DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS HOFFMANN LA ROCHE (CH) 2014-07-09 EP claimed
EP-2183245-A2 DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS F. Hoffmann-Roche AG (CH) 2010-05-12 EP claimed
WO-2009013212-A2 DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS F. HOFFMANN-LA ROCHE AG (CH) 2009-01-29 WO claimed
EP-2183245-B1 DUAL MODULATORS OF 5-HT2A AND D3 RECEPTORS HOFFMANN LA ROCHE (CH) 2014-07-09 EP disclosed