Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15818242 | 0.93 | PIK3CD (0.55) | PIK3CDPIK3R1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL16584706 | 0.90 | PIK3CD (0.67) | PIK3CDPIK3R1LMNASMN1; SMN2PDE10A | |
| SCHEMBL15818750 | 0.89 | PIK3CD (0.46) | PIK3CDPIK3R1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL20595353 | 0.88 | LMNA (0.44) | PIK3CDLMNAMAPK1SMN1; SMN2PDE10A | |
| SCHEMBL16586945 | 0.88 | LMNA (0.44) | PIK3CDLMNAMAPK1SMN1; SMN2PDE10A | |
| SCHEMBL16584915 | 0.88 | PDE10A (0.52) | PIK3CDPIK3R1LMNAMAPK1PDE10A | |
| SCHEMBL20595441 | 0.86 | LMNA (0.43) | PIK3CDLMNAMAPK1SMN1; SMN2PDE10A | |
| SCHEMBL20595345 | 0.86 | LMNA (0.43) | PIK3CDPIK3R1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL20595317 | 0.85 | PDE10A (0.43) | PIK3CDPIK3R1LMNAMAPK1SMN1; SMN2 | |
| SCHEMBL18076650 | 0.85 | MAPK1 (0.61) | LMNAMAPK1SMN1; SMN2PDE10AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Calitor Sciences, LLC (US) | 2016-07-27 | — | — | EP | disclosed |
| WO-2015042077-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2014106800-A2 | SUBSTITUTED 2-AMINO PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2014-07-10 | — | — | WO | disclosed |