Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15864461 | 0.86 | PIK3CD (0.53) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL16586945 | 0.83 | LMNA (0.44) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL20595353 | 0.83 | LMNA (0.44) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL16584915 | 0.83 | PDE10A (0.52) | LMNAMAPK1PDE10APIK3CDMAPT | |
| SCHEMBL20595317 | 0.83 | PDE10A (0.43) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL20595345 | 0.82 | LMNA (0.43) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL18076650 | 0.81 | MAPK1 (0.61) | LMNAMAPK1SMN1; SMN2PDE10AMEN1 | |
| SCHEMBL15818242 | 0.80 | PIK3CD (0.55) | LMNAMAPK1SMN1; SMN2PDE10APIK3CD | |
| SCHEMBL21178507 | 0.78 | PIK3CD (0.45) | LMNAMAPK1PDE10APIK3CDPIK3CA | |
| SCHEMBL16584706 | 0.77 | PIK3CD (0.67) | LMNASMN1; SMN2PDE10APIK3CDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018237007-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE AND HISTONE DEACETYLASE FOR TREATMENT OF CANCER | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2018-12-27 | — | — | WO | disclosed |