Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15864661 | 0.89 | LRRK2 (0.65) | LRRK2KITPIK3CAMTORKCNH2 | |
| SCHEMBL15865168 | 0.89 | LRRK2 (0.65) | LRRK2PIK3CAMTORKCNH2PIK3C3 | |
| SCHEMBL15865510 | 0.89 | LRRK2 (0.65) | LRRK2PIK3CAMTORKCNH2PIK3C3 | |
| SCHEMBL15865279 | 0.87 | LRRK2 (0.59) | LRRK2PIK3CAMTORKCNH2PIK3C3 | |
| SCHEMBL15864772 | 0.80 | LRRK2 (0.64) | LRRK2KCNH2METJAK2JAK1 | |
| SCHEMBL29857636 | 0.80 | LRRK2 (1.00) | LRRK2KIT | |
| SCHEMBL15864655 | 0.80 | LRRK2 (1.00) | LRRK2KIT | |
| SCHEMBL15864511 | 0.79 | LRRK2 (0.65) | LRRK2KCNH2PIK3C3MET | |
| SCHEMBL19086091 | 0.73 | LRRK2 (0.64) | LRRK2KCNH2JAK2 | |
| SCHEMBL15865262 | 0.73 | LRRK2 (0.64) | LRRK2KCNH2METAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. Lundbeck A/S (DK) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106612-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-10 | — | — | WO | disclosed |