Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15864661 | 0.82 | LRRK2 (0.65) | LRRK2KCNH2JAK2JAK1TYK2 | |
| SCHEMBL15865168 | 0.81 | LRRK2 (0.65) | LRRK2KCNH2MET | |
| SCHEMBL15865510 | 0.81 | LRRK2 (0.65) | LRRK2KCNH2MET | |
| SCHEMBL15865279 | 0.81 | LRRK2 (0.59) | LRRK2KCNH2MET | |
| SCHEMBL15864658 | 0.80 | LRRK2 (0.66) | LRRK2KCNH2JAK2JAK1TYK2 | |
| SCHEMBL15864511 | 0.79 | LRRK2 (0.65) | LRRK2KCNH2MET | |
| SCHEMBL17271364 | 0.78 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL19086091 | 0.76 | LRRK2 (0.64) | LRRK2KCNH2JAK2 | |
| SCHEMBL15865262 | 0.76 | LRRK2 (0.64) | LRRK2KCNH2MET | |
| SCHEMBL19086093 | 0.75 | LRRK2 (0.64) | LRRK2MAPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. Lundbeck A/S (DK) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106612-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-10 | — | — | WO | disclosed |