Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.64 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086091 | 0.88 | LRRK2 (0.64) | LRRK2KCNH2 | |
| SCHEMBL19086093 | 0.82 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL15865279 | 0.81 | LRRK2 (0.59) | LRRK2ALOX5APFEN1KCNH2MET | |
| SCHEMBL15865510 | 0.80 | LRRK2 (0.65) | LRRK2ALOX5APFEN1KCNH2MET | |
| SCHEMBL15864797 | 0.78 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864772 | 0.76 | LRRK2 (0.64) | LRRK2KCNH2MET | |
| SCHEMBL15864661 | 0.75 | LRRK2 (0.65) | LRRK2KCNH2MET | |
| SCHEMBL15865168 | 0.75 | LRRK2 (0.65) | LRRK2KCNH2MET | |
| SCHEMBL15864658 | 0.73 | LRRK2 (0.66) | LRRK2AXLMERTKKCNH2MET | |
| SCHEMBL15864636 | 0.73 | LRRK2 (0.48) | LRRK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. Lundbeck A/S (DK) | 2015-11-11 | — | — | EP | disclosed |
| WO-2014106612-A1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H. LUNDBECK A/S (DK) | 2014-07-10 | — | — | WO | disclosed |