Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 15/20 | 0.64 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19086091 | 0.83 | LRRK2 (0.64) | LRRK2JAK2 | |
| SCHEMBL15865262 | 0.82 | LRRK2 (0.64) | LRRK2 | |
| SCHEMBL15864511 | 0.81 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL15865334 | 0.78 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL15864772 | 0.75 | LRRK2 (0.64) | LRRK2JAK2MAPT | |
| SCHEMBL15865168 | 0.73 | LRRK2 (0.65) | LRRK2 | |
| SCHEMBL15864661 | 0.71 | LRRK2 (0.65) | LRRK2JAK2 | |
| SCHEMBL15864859 | 0.70 | LRRK2 (0.47) | LRRK2USP7 | |
| SCHEMBL19112998 | 0.70 | LRRK2 (0.54) | LRRK2USP7 | |
| SCHEMBL15864642 | 0.67 | LRRK2 (0.49) | LRRK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2941425-B1 | AMINOPYRIDINE DERIVED COMPOUNDS AS LRRK2 INHIBITORS | H LUNDBECK AS (DK) | 2017-07-12 | — | — | EP | claimed |