Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 7/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.54 |
| ▸ | ECE1 | P42892 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.52 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.52 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 3/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.51 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17742350 | 0.84 | SIRT2 (0.69) | MMP3SIRT2SIRT1ECE1SIRT5 | |
| SCHEMBL6287961 | 0.82 | SIRT2 (0.60) | MMP3SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL7322118 | 0.81 | SIRT2 (0.62) | SIRT2SIRT1ECE1ITGB3ITGA2B | |
| SCHEMBL7322113 | 0.81 | SIRT2 (0.62) | SIRT2SIRT1ECE1ITGB3ITGA2B | |
| 2S,4R-4-Methylglutamate SCHEMBL15519374 | 0.81 | CPB1 (0.57) | SIRT2SIRT1ECE1ITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL7982992 | 0.80 | SIRT2 (0.61) | SIRT2SIRT1ECE1ITGB3ITGA2B | |
| SCHEMBL13411034 | 0.80 | SSTR3 (0.55) | MMP3SIRT2SIRT1ECE1KDM1A | |
| SCHEMBL13410990 | 0.80 | SSTR3 (0.55) | MMP3SIRT2SIRT1ECE1KDM1A | |
| SCHEMBL13411016 | 0.80 | SSTR3 (0.55) | MMP3SIRT2SIRT1ECE1KDM1A | |
| SCHEMBL13411008 | 0.80 | SSTR3 (0.55) | MMP3SIRT2SIRT1ECE1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8802632-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-08-12 | — | — | US | disclosed |
| US-8772543-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, L.L.C. (US) | 2014-07-08 | — | — | US | disclosed |