Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 10/20 | 0.60 |
| ▸ | SIRT1 | Q96EB6 | 9/20 | 0.60 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.60 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17742350 | 0.92 | SIRT2 (0.69) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| SCHEMBL1674876 | 0.86 | SSTR3 (0.64) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| SCHEMBL7322113 | 0.84 | SIRT2 (0.62) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL7322118 | 0.84 | SIRT2 (0.62) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL8130735 | 0.83 | SIRT5 (0.58) | SIRT2SIRT1SIRT5SIRT3HDAC1 | |
| Hydrochloric Acid SCHEMBL7982992 | 0.83 | SIRT2 (0.61) | SIRT2SIRT1SIRT5SIRT3 | |
| SCHEMBL15865985 | 0.82 | MMP3 (0.55) | SIRT2SIRT1SIRT5SIRT3MMP3 | |
| SCHEMBL15968143 | 0.81 | ITGB3 (0.66) | SIRT2SIRT1SIRT3 | |
| SCHEMBL287475 | 0.81 | ITGB3 (0.66) | SIRT2SIRT1SIRT3 | |
| SCHEMBL9086439 | 0.81 | ITGB3 (0.60) | SIRT2SIRT1SIRT3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887890-B2 | Compounds exhibiting thrombopoietin-like activities | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2005-05-03 | — | — | US | disclosed |