Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14000831 | 0.77 | SMN1; SMN2 (0.42) | TSHRMAPTSMN1; SMN2RECQLCYP1A1 | |
| SCHEMBL14276072 | 0.77 | SMN1; SMN2 (0.42) | TSHRMAPTSMN1; SMN2RECQLCYP1A1 | |
| SCHEMBL9944273 | 0.77 | KDM4E (0.37) | TSHRMAPTSMN1; SMN2RECQLHTT | |
| SCHEMBL11871700 | 0.76 | TSHR (0.51) | TSHRMAPTSMN1; SMN2RECQLHTT | |
| SCHEMBL11871705 | 0.76 | TSHR (0.51) | TSHRMAPTSMN1; SMN2RECQLHTT | |
| SCHEMBL18680537 | 0.74 | GPR119 (0.33) | MAPTKMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL951889 | 0.71 | TSHR (0.46) | TSHRMAPTSMN1; SMN2RECQLHTT | |
| SCHEMBL9371358 | 0.70 | ATM (0.50) | TSHRMAPTSMN1; SMN2HTTCYP1A1 | |
| SCHEMBL9371354 | 0.70 | ATM (0.50) | TSHRMAPTSMN1; SMN2HTTCYP1A1 | |
| SCHEMBL4981459 | 0.70 | LMNA (0.41) | MAPTSMN1; SMN2HTTCYP1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772290-B2 | Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same | Oscotech Inc. (KR) | 2014-07-08 | — | — | US | disclosed |