Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17319162 | 0.81 | FAAH (0.47) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL17319165 | 0.79 | FAAH (0.47) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL15884071 | 0.78 | FAAH (0.44) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL15861707 | 0.77 | STIM1 (0.40) | KDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15868122 | 0.77 | SMN1; SMN2 (0.45) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL15869830 | 0.77 | CHRNA7 (0.47) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL15884061 | 0.76 | FAAH (0.44) | FAAHGABRG2GABRB3GABRA5MMP2 | |
| SCHEMBL15868145 | 0.75 | FAAH (0.44) | FAAHMMP2MMP13MMP14BRD4 | |
| SCHEMBL15861703 | 0.74 | PIM2 (0.41) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15869839 | 0.74 | FAAH (0.43) | FAAHMMP2MMP13MMP14KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| WO-2014108337-A1 | PYRAZOLYL-BASED CARBOXAMIDES I AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | AADAC, HDAC3, NLRP3 | FAAH 1038/4885GABRG2 1861/4885GABRB3 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.