Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 1/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15884137 | 0.85 | FAAH (0.43) | FAAHMMP13MMP2MMP14NR1H2 | |
| SCHEMBL15868131 | 0.85 | FAAH (0.43) | FAAHMMP13MMP2MMP14NR1H2 | |
| SCHEMBL15868139 | 0.84 | FAAH (0.42) | FAAHMMP13MMP2MMP14CA9 | |
| SCHEMBL15868126 | 0.83 | PTGDR2 (0.44) | FAAHMMP13MMP2MMP14KCNB1 | |
| SCHEMBL15884141 | 0.80 | KCNB1 (0.43) | KCNB1PTGDR2GRM5FFAR1 | |
| SCHEMBL1779589 | 0.79 | CA9 (0.59) | FAAHMMP13MMP2MMP14NR1H2 | |
| SCHEMBL4496559 | 0.78 | FAAH (0.57) | FAAHMMP13MMP2MMP14NR1H2 | |
| SCHEMBL30130655 | 0.78 | FAAH (0.57) | FAAHMMP13MMP2MMP14NR1H2 | |
| SCHEMBL5078585 | 0.78 | KAT6A (0.49) | KCNB1PTGDR2 | |
| SCHEMBL15861665 | 0.76 | STIM1 (0.49) | CTSANPC1RAB9ASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-9206136-B2 | Pyrazolyl-based carboxamides I | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| WO-2014108337-A1 | PYRAZOLYL-BASED CARBOXAMIDES I AS CRAC CHANNEL INHIBITORS | Grünenthal GmbH (DE) | 2014-07-17 | — | — | WO | disclosed |
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | Grünenthal GmbH (DE) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194443-A1 | Pyrazolyl-Based Carboxamides I | AADAC, HDAC3, NLRP3 | FAAH 1038/4885MMP13 3001/4885MMP2 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.