Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CAT | P04040 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.30 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.30 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.30 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17337357 | 0.88 | PARP1 (0.37) | PARP1NPSR1LMNACATMAPT | |
| SCHEMBL17337290 | 0.88 | PARP1 (0.37) | PARP1NPSR1LMNACATMAPT | |
| SCHEMBL18827396 | 0.87 | PARP1 (0.36) | PARP1LMNACATMAPTCASP3 | |
| SCHEMBL18683713 | 0.87 | PARP1 (0.36) | PARP1LMNACATMAPTCASP3 | |
| SCHEMBL23129914 | 0.86 | PARP1 (0.36) | PARP1LMNACATMAPT | |
| SCHEMBL17347389 | 0.86 | PARP1 (0.36) | PARP1LMNACATMAPT | |
| SCHEMBL15861578 | 0.86 | ALDH1A1 (0.34) | PARP1 | |
| SCHEMBL15861579 | 0.86 | ALDH1A1 (0.34) | PARP1 | |
| SCHEMBL15861664 | 0.85 | PARP1 (0.36) | PARP1LMNACATMAPT | |
| SCHEMBL15861663 | 0.85 | PARP1 (0.36) | PARP1LMNACATMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9642869-B2 | Boronic acid derivatives and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2017-05-09 | — | — | US | disclosed |
| US-9101638-B2 | Boronic acid derivatives and therapeutic uses thereof | REMPEX PHARMACEUTICALS, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-20140194385-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | QPEX BIOPHARMA, INC. | 2014-07-10 | — | — | US | disclosed |
| US-20140194382-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | THE MEDICINES COMPANY (SAN DIEGO), LLC | 2014-07-10 | — | — | US | disclosed |
| WO-2014107535-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | REMPEX PHARMACEUTICALS, INC. (US) | 2014-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194385-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | BPGM, GCG, GBA1 | PARP1 1847/4885PKM 2656/4885NPSR1 3626/4885 |
| US-20140194382-A1 | BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF | BCL6B, BTD, BCL6 | PARP1 1238/4885PKM 3196/4885NPSR1 3681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.