Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15869297 | 0.87 | AHR (0.45) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869295 | 0.87 | AHR (0.45) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869294 | 0.86 | AHR (0.43) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869298 | 0.82 | AHR (0.40) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869296 | 0.82 | AHR (0.40) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL18826569 | 0.80 | HPGD (0.71) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869299 | 0.80 | AHR (0.38) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL10820300 | 0.78 | RAB9A (0.43) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL15869300 | 0.77 | RAB9A (0.37) | AHRMAOAKDM4EALDH1A1HPGD | |
| SCHEMBL11437146 | 0.77 | AHR (0.58) | AHRMAOAKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9642836-B2 | Isotopologues of isoindole derivatives | CELGENE CORPORATION (US) | 2017-05-09 | — | — | US | disclosed |
| US-20150258063-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | AMGEN INC. | 2015-09-17 | — | — | US | disclosed |
| US-9045417-B2 | Isotopologues of isoindole derivatives | CELGENE CORPORATION (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140194485-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | CELGENE CORPORATION (US) | 2014-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140194485-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | IDO1, CYP11B2, IDO2 | AHR 85/4885MAOA 556/4885KDM4E 2562/4885 |
| US-20150258063-A1 | ISOTOPOLOGUES OF ISOINDOLE DERIVATIVES | IDO1, CYP11B2, IDO2 | AHR 85/4885MAOA 556/4885KDM4E 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.