Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.82 |
| ▸ | MEN1 | O00255 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | RECQL | P46063 | 3/20 | 0.82 |
| ▸ | BLM | P54132 | 3/20 | 0.82 |
| ▸ | ESR1 | P03372 | 3/20 | 0.82 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.82 |
| ▸ | GAA | P10253 | 2/20 | 0.82 |
| ▸ | HPGD | P15428 | 2/20 | 0.82 |
| ▸ | THRB | P10828 | 2/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.82 |
| ▸ | MAOA | P21397 | 2/20 | 0.82 |
| ▸ | MGAM | O43451 | 1/20 | 0.82 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | GLA | P06280 | 1/20 | 0.82 |
| ▸ | POLB | P06746 | 1/20 | 0.82 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Coumestrol SCHEMBL22012 | 0.90 | ESR2 (1.00) | KMT2AMEN1KDM4EMAPTRECQL | |
| Coumestrol SCHEMBL29453366 | 0.90 | ESR2 (1.00) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL15870374 | 0.89 | ESR2 (0.84) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL5918258 | 0.85 | MEN1 (0.68) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL2439156 | 0.84 | KDM4E (1.00) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL30004934 | 0.83 | KDM4E (0.85) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL29603115 | 0.83 | ESR2 (0.74) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL15870371 | 0.83 | KDM4E (0.85) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL234819 | 0.83 | KDM4E (0.85) | KMT2AMEN1KDM4EMAPTRECQL | |
| SCHEMBL30006760 | 0.83 | KDM4E (0.85) | KMT2AMEN1KDM4EMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | BG NEGEV TECHNOLOGIES & APPLIC LTD (IL) | 2015-11-26 | — | — | US | disclosed |
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | BG NEGEV TECHNOLOGIES & APPLIC LTD (IL) | 2015-11-26 | — | — | US | disclosed |
| WO-2014106848-A1 | COUMESTAN, COUMESTROL, COUMESTAN DERIVATIVES AND PROCESSES OF MAKING THE SAME AND USES OF SAME | B.G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD. (IL) | 2014-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336977-A1 | Coumestan, Coumestrol, Coumestan Derivatives and Processes of Making the Same and Uses of Same | CYP19A1, ESR1, GPER1 | KMT2A 1357/4885MEN1 954/4885KDM4E 880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.