Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 7/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.38 |
| ▸ | FEN1 | P39748 | 4/20 | 0.38 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15870516 | 0.82 | TRPV3 (0.48) | TRPV3MAPTGSK3B | |
| SCHEMBL15870511 | 0.79 | CCNC (0.53) | FGFR1FGFR2 | |
| SCHEMBL15870487 | 0.79 | FYN (0.46) | TRPV3ALOX5APFEN1 | |
| SCHEMBL15870503 | 0.71 | TRPV3 (0.47) | TRPV3CYP3A4FGFR2CYP2C9CYP2C19 | |
| SCHEMBL15870550 | 0.69 | CSF1R (0.39) | TRPV3MAPT | |
| SCHEMBL21518744 | 0.66 | CYP11B1 (0.36) | CYP3A4CYP17A1CYP11B1CYP11B2 | |
| SCHEMBL15870606 | 0.64 | TRPV3 (0.50) | TRPV3 | |
| SCHEMBL15870576 | 0.64 | FYN (0.68) | ALOX5APFEN1USP7 | |
| SCHEMBL38659424 | 0.64 | ESR1 (0.70) | ESR1ESR2CYP3A4FGFR1FGFR2 | |
| SCHEMBL28226426 | 0.64 | ESR1 (0.70) | ESR1ESR2CYP3A4FGFR1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014106606-A1 | NOVE PHENYL/PYRIDINE SERIES SUBSTITUED BY HYDROXYETHYLAMINO FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2014-07-10 | — | — | WO | disclosed |