Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17254424 | 1.00 | MAPT (0.43) | MAPTALDH1A1LMNACTPS1GAA | |
| SCHEMBL17254425 | 1.00 | MAPT (0.43) | MAPTALDH1A1LMNACTPS1GAA | |
| SCHEMBL15874919 | 0.85 | PIM2 (0.39) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL15874915 | 0.85 | PIM2 (0.39) | MAPTPIM2PIM1PIM3 | |
| SCHEMBL16515825 | 0.83 | PIM2 (0.40) | MAPTALDH1A1GAAPIM2PIM1 | |
| SCHEMBL16515822 | 0.83 | PIM2 (0.40) | MAPTALDH1A1GAAPIM2PIM1 | |
| SCHEMBL18259439 | 0.81 | MAPT (0.46) | MAPTALDH1A1LMNAPIM2PIM1 | |
| SCHEMBL13456916 | 0.81 | MAPT (0.46) | MAPTALDH1A1LMNAPIM2PIM1 | |
| SCHEMBL18284067 | 0.80 | MAPT (0.37) | MAPTALDH1A1LMNACTPS1GAA | |
| SCHEMBL15913504 | 0.77 | MAPT (0.42) | MAPTALDH1A1LMNAPIM2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943485-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | Incyte Corporation (US) | 2015-11-18 | — | — | EP | disclosed |
| US-9187486-B2 | Bicyclic pyridazine compounds as Pim inhibitors | AMGEN INC. (US) | 2015-11-17 | — | — | US | disclosed |
| WO-2014110574-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION (US) | 2014-07-17 | — | — | WO | disclosed |