⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000059 | 0.76 | TSHR (0.32) | — | |
| SCHEMBL3489284 | 0.68 | — | — | |
| SCHEMBL517723 | 0.66 | TSHR (0.41) | — | |
| SCHEMBL8595019 | 0.66 | — | — | |
| SCHEMBL7533595 | 0.66 | — | — | |
| SCHEMBL20606630 | 0.65 | TSHR (0.35) | — | |
| SCHEMBL8579001 | 0.64 | CA2 (0.33) | — | |
| SCHEMBL8919030 | 0.64 | TSHR (0.31) | — | |
| SCHEMBL1070151 | 0.64 | — | — | |
| SCHEMBL11891895 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180066009-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | CHEMGENES CORP (US) | 2018-03-08 | — | — | US | disclosed |
| US-9718855-B2 | Nucleosides and oligonucleotides for studies on reversal of cytotoxic and mutagenic damage of DNA and as diagnostics tools | CHEMGENES CORPORATION (US) | 2017-08-01 | — | — | US | disclosed |
| US-20140350234-A1 | Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools | CHEMGENES CORPORATION (US) | 2014-11-27 | — | — | US | disclosed |
| US-8785619-B1 | Nucleosides and oligonucleotides for studies on reversal of cytotoxic and mutagenic damage of DNA potential diagnostics tools | CHEMGENES CORPORATION (US) | 2014-07-22 | — | — | US | disclosed |