Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15890993 | 1.00 | MAPT (0.53) | MAPTPTGS1AKR1C3EPHX2AKR1C2 | |
| SCHEMBL31293405 | 0.84 | RECQL (0.50) | MAPTPTGS1AKR1C3AKR1C2FBP1 | |
| SCHEMBL1655140 | 0.84 | RECQL (0.50) | MAPTPTGS1AKR1C3AKR1C2FBP1 | |
| SCHEMBL1655139 | 0.84 | RECQL (0.50) | MAPTPTGS1AKR1C3AKR1C2FBP1 | |
| SCHEMBL1579813 | 0.82 | TBXAS1 (0.48) | AKR1C3EPHX2TBXAS1CYP3A4CYP2C9 | |
| SCHEMBL14032639 | 0.82 | EPHX2 (0.47) | MAPTPTGS1EPHX2FBP1PTGS2 | |
| SCHEMBL6338925 | 0.82 | KDM4E (0.58) | EPHX2TBXAS1CYP3A4CYP2C9 | |
| SCHEMBL20184163 | 0.82 | KDM4E (0.58) | EPHX2TBXAS1CYP3A4CYP2C9 | |
| SCHEMBL2391183 | 0.82 | KDM4E (0.58) | EPHX2TBXAS1CYP3A4CYP2C9 | |
| SCHEMBL1579814 | 0.82 | TBXAS1 (0.48) | AKR1C3EPHX2TBXAS1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791119-B2 | 3,4-dihydropyrrolo[1,2-A]pyrazine-2,8(1H)-dicarboxamide derivatives, preparation thereof and therapeutic use thereof for diseases involving casein kinase 1 epsilon and/or casein kinase 1 delta | SANOFI (FR) | 2014-07-29 | — | — | US | disclosed |