Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655140 | 1.00 | RECQL (0.50) | RECQLTSHRCYP2C19AKR1C3AKR1C2 | |
| SCHEMBL1655139 | 1.00 | RECQL (0.50) | RECQLTSHRCYP2C19AKR1C3AKR1C2 | |
| SCHEMBL15890992 | 0.84 | MAPT (0.53) | AKR1C3AKR1C2FBP1NFE2L2MAPT | |
| SCHEMBL15890993 | 0.84 | MAPT (0.53) | AKR1C3AKR1C2FBP1NFE2L2MAPT | |
| SCHEMBL2224096 | 0.81 | RECQL (0.72) | RECQLTSHRCYP2C19AKR1C3MAPT | |
| SCHEMBL166780 | 0.81 | RECQL (0.72) | RECQLTSHRCYP2C19AKR1C3MAPT | |
| SCHEMBL5032754 | 0.81 | RECQL (0.72) | RECQLTSHRCYP2C19AKR1C3MAPT | |
| SCHEMBL27158696 | 0.81 | RECQL (0.72) | RECQLTSHRCYP2C19AKR1C3MAPT | |
| SCHEMBL1655835 | 0.81 | RECQL (0.50) | RECQLTSHRCYP2C19AKR1C3AKR1C2 | |
| SCHEMBL1655838 | 0.81 | RECQL (0.50) | RECQLTSHRCYP2C19AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735449-A1 | TETRACYCLIC COMPOUNDS CONTAINING A FUSED INDOLE FOR TREATING APOL1-MEDIATED CHRONIC KIDNEY DISEASE | OmniAB, Inc. (US) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006262-A1 | TETRACYCLIC COMPOUNDS CONTAINING A FUSED INDOLE FOR TREATING APOL1-MEDIATED CHRONIC KIDNEY DISEASE | OMNIAB, INC. (US) | 2025-01-02 | — | — | WO | disclosed |