Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PARG | Q86W56 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | BRD2 | P25440 | 1/20 | 0.48 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PKLR | P30613 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13432804 | 0.93 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2ABRD4KDM4E | |
| SCHEMBL14250451 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL13469348 | 0.84 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL14249971 | 0.84 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL14314606 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL18275123 | 0.83 | KDM4E (0.61) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL27885422 | 0.82 | ALDH1A1 (0.52) | ALDH1A1LMNAKMT2AHTR6TDP1 | |
| SCHEMBL18151417 | 0.81 | ALDH1A1 (0.58) | ALDH1A1LMNAKMT2ATDP1PARG | |
| SCHEMBL1710571 | 0.80 | LMNA (0.54) | ALDH1A1LMNAKMT2AHTR6BRD4 | |
| SCHEMBL3389722 | 0.79 | ALDH1A1 (0.53) | ALDH1A1LMNAKMT2AHTR6BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937652-B1 | PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS | AVENTIS PHARMA INC (US) | 2014-07-30 | — | — | EP | claimed |