Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | F2 | P00734 | 3/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.49 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.49 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15625455 | 0.85 | CA1 (0.62) | TSHRPKMF2PRSS1PRSS2 | |
| SCHEMBL2854385 | 0.83 | LMNA (0.56) | TDP1ALDH1A1LMNAF2PRSS1 | |
| SCHEMBL15625460 | 0.83 | SLC40A1 (0.53) | DHFRTSHRSMN1; SMN2TDP1PKM | |
| SCHEMBL6161386 | 0.83 | MEN1 (0.60) | LMNAF2PRSS1PRSS2PRSS3 | |
| SCHEMBL5566210 | 0.81 | CA1 (0.56) | SMN1; SMN2ALDH1A1LMNAF2PRSS1 | |
| SCHEMBL6297904 | 0.80 | TSHR (0.64) | DHFRTSHRSMN1; SMN2TDP1PKM | |
| SCHEMBL4071822 | 0.80 | SMN1; SMN2 (0.68) | DHFRTSHRSMN1; SMN2TDP1PKM | |
| SCHEMBL2850555 | 0.79 | LMNA (0.53) | SMN1; SMN2TDP1ALDH1A1LMNAF2 | |
| SCHEMBL5041352 | 0.79 | LMNA (0.61) | SMN1; SMN2ALDH1A1LMNAF2PRSS1 | |
| SCHEMBL3649154 | 0.79 | PTPN11 (0.57) | ALDH1A1LMNAF2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937652-B1 | PYRIMIDINE AMIDE COMPOUNDS AS PGDS INHIBITORS | AVENTIS PHARMA INC (US) | 2014-07-30 | — | — | EP | claimed |