Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17508276 | 0.89 | NPSR1 (0.79) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL2353958 | 0.86 | LMNA (0.66) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL1201051 | 0.85 | LMNA (0.75) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL31599176 | 0.81 | LMNA (0.88) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL7921286 | 0.79 | LMNA (0.61) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL95238 | 0.79 | LMNA (1.00) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL29361707 | 0.79 | LMNA (1.00) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| Benzene SCHEMBL27888748 | 0.79 | LMNA (1.00) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL2999532 | 0.79 | LMNA (0.77) | NPSR1LMNAKMT2AGAAALDH1A1 | |
| SCHEMBL733917 | 0.78 | NPSR1 (0.59) | NPSR1LMNAKMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948456-A1 | BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014114249-A1 | BICYCLIC PYRIMIDONE COMPOUNDS AS INHIBITORS OF LP-PLA2 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-31 | — | — | WO | disclosed |