Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.47 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8393465 | 0.90 | LMNA (0.73) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL1200307 | 0.87 | ALDH1A1 (1.00) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31599176 | 0.81 | LMNA (0.88) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL2074740 | 0.79 | ALDH1A1 (0.68) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL7909540 | 0.79 | ABCB1 (0.56) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL95238 | 0.79 | LMNA (1.00) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29361707 | 0.79 | LMNA (1.00) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| Benzene SCHEMBL27888748 | 0.79 | LMNA (1.00) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15903754 | 0.79 | NPSR1 (0.65) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| 2-Methoxybenzaldehyde SCHEMBL8469378 | 0.78 | ALDH1A1 (0.66) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394794-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100197686-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2010-08-05 | — | — | US | disclosed |
| WO-2008118802-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197686-A1 | THERAPEUTIC COMPOUNDS | ABCC1, ABCB1, MCL1 | LMNA 4541/4885ALDH1A1 266/4885CYP1A2 2715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.