Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13653845 | 0.71 | HEXA (0.41) | NOS3NOS2 | |
| SCHEMBL15904125 | 0.69 | PDE10A (0.40) | — | |
| SCHEMBL15904190 | 0.68 | — | — | |
| SCHEMBL15904001 | 0.67 | PDE10A (0.41) | — | |
| SCHEMBL11424150 | 0.67 | PDE10A (0.43) | — | |
| SCHEMBL30487819 | 0.67 | KMT2A (0.39) | — | |
| SCHEMBL2549958 | 0.67 | KMT2A (0.39) | — | |
| SCHEMBL10916223 | 0.67 | PKM (0.35) | — | |
| Hydrochloric Acid SCHEMBL11431163 | 0.65 | PDE10A (0.42) | — | |
| SCHEMBL19637150 | 0.65 | HTT (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-B | Pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | 帕罗生物制药有限公司 | 2018-11-13 | — | — | CN | disclosed |
| EP-2948443-A1 | NEW PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS (PDE-10) | PALOBIOFARMA S.L. (ES) | 2015-12-02 | — | — | EP | disclosed |
| WO-2014114695-A1 | NEW PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS (PDE-10) | PALOBIOFARMA S.L (ES) | 2014-07-31 | — | — | WO | disclosed |