Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | YEATS4 | O95619 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19396273 | 0.92 | ALDH1A1 (0.40) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL19396275 | 0.88 | ALDH1A1 (0.43) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL1593798 | 0.86 | ALDH1A1 (0.59) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL17624645 | 0.84 | MAPT (0.47) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL19396271 | 0.82 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL12589838 | 0.81 | MAPK14 (0.49) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL19396274 | 0.81 | ALDH1A1 (0.42) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL19396253 | 0.80 | NPC1 (0.56) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL12589839 | 0.80 | ALDH1A1 (0.44) | ALDH1A1NPC1RAB9AKDM4EMAPT | |
| SCHEMBL12589837 | 0.79 | ALDH1A1 (0.41) | ALDH1A1NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791137-B2 | Therapeutic compounds | DART NEUROSCIENCE (CAYMAN) LTD. (KY) | 2014-07-29 | — | — | US | disclosed |