Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.81 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.80 |
| ▸ | TSHR | P16473 | 1/20 | 0.80 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.80 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.80 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | PRKACG | P22612 | 1/20 | 0.57 |
| ▸ | PRKACB | P22694 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1106661 | 1.00 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL13639048 | 1.00 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL13300472 | 1.00 | PDE4A (0.81) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL29359388 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL16079734 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL5951342 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL13300468 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL2713659 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL29384358 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DRAPGEF3 | |
| SCHEMBL14260882 | 0.89 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DRAPGEF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765844-B1 | PURINE NUCLEOTIDE DERIVATIVES | SOLVELL AS (NO) | 2014-07-30 | — | — | EP | disclosed |