Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | INSR | P06213 | 1/20 | 0.61 |
| ▸ | IGF1R | P08069 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | TXK | P42681 | 1/20 | 0.61 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13894046 | 0.93 | BTK (0.67) | BTK | |
| SCHEMBL105806 | 0.86 | BTK (0.75) | BTK | |
| SCHEMBL1069382 | 0.84 | BTK (1.00) | BTKJAK2INSRIGF1RCYP3A4 | |
| SCHEMBL5242071 | 0.83 | BTK (0.66) | BTKJAK2INSRIGF1RCYP3A4 | |
| SCHEMBL13893891 | 0.82 | BTK (0.61) | BTK | |
| SCHEMBL13893941 | 0.81 | BTK (0.55) | BTKJAK2INSRIGF1RCYP3A4 | |
| SCHEMBL3999908 | 0.81 | BTK (1.00) | BTKJAK2INSRIGF1RCYP3A4 | |
| SCHEMBL769731 | 0.81 | BTK (1.00) | BTK | |
| SCHEMBL29359902 | 0.81 | BTK (1.00) | BTK | |
| SCHEMBL1066164 | 0.81 | BTK (1.00) | BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205564-B1 | NOVEL KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2014-07-30 | — | — | EP | disclosed |