Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.69 |
| ▸ | HTR2A | P28223 | 10/20 | 0.69 |
| ▸ | HTR2C | P28335 | 4/20 | 0.69 |
| ▸ | HRH1 | P35367 | 4/20 | 0.69 |
| ▸ | DRD3 | P35462 | 4/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.69 |
| ▸ | DRD1 | P21728 | 3/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.69 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.69 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.69 |
| ▸ | DRD4 | P21917 | 2/20 | 0.69 |
| ▸ | DRD5 | P21918 | 2/20 | 0.69 |
| ▸ | HTR1D | P28221 | 2/20 | 0.69 |
| ▸ | HTR1B | P28222 | 2/20 | 0.69 |
| ▸ | HTR7 | P34969 | 2/20 | 0.69 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.69 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.69 |
| ▸ | ACHE | P22303 | 3/20 | 0.63 |
| ▸ | HTR1A | P08908 | 3/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6881431 | 0.97 | DRD2 (0.67) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL1958487 | 0.92 | HTR2A (0.73) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL15907987 | 0.91 | DRD2 (0.65) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL21074540 | 0.90 | DRD2 (0.64) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL19484373 | 0.90 | HTR2A (0.76) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL15489555 | 0.89 | DRD2 (0.68) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL1961482 | 0.89 | DRD2 (0.72) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL6881873 | 0.89 | DRD2 (0.72) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL24018542 | 0.89 | DRD2 (0.71) | DRD2HTR2AHTR2CHRH1DRD3 | |
| SCHEMBL21295308 | 0.89 | DRD2 (0.71) | DRD2HTR2AHTR2CHRH1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3556759-B1 | HAPTENS OF PALIPERIDONE | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-29 | — | — | EP | disclosed |
| EP-3556759-A1 | HAPTENS OF PALIPERIDONE | Janssen Pharmaceutica NV (BE) | 2019-10-23 | — | — | EP | disclosed |
| EP-2888258-B1 | HAPTENS OF PALIPERIDONE | JANSSEN PHARMACEUTICA NV (BE) | 2019-06-05 | — | — | EP | disclosed |
| US-9394354-B2 | Haptens of paliperidone | JANSSEN PHARMACEUTICA NV (BE) | 2016-07-19 | — | — | US | disclosed |
| US-9394354-B2 | Haptens of paliperidone | JANSSEN PHARMACEUTICA NV (BE) | 2016-07-19 | — | — | US | disclosed |
| US-20140213767-A1 | HAPTENS OF PALIPERIDONE | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| US-20140213767-A1 | HAPTENS OF PALIPERIDONE | ORTHO-CLINICAL DIAGNOSTICS, INC. (US) | 2014-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140213767-A1 | HAPTENS OF PALIPERIDONE | CD274, PIN1, LY96 | DRD2 430/4885HTR2A 864/4885HTR2C 735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.