Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 17/20 | 0.36 |
| ▸ | MAPT | P10636 | 15/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15908924 | 0.84 | ARF6 (0.42) | POLBLMNAKDM4EALDH1A1GAA | |
| SCHEMBL15909027 | 0.84 | POLB (0.41) | POLBMAPTRXFP1LMNATHRB | |
| SCHEMBL15908944 | 0.84 | HTT (0.39) | POLBMAPTRXFP1LMNATHRB | |
| SCHEMBL1279401 | 0.83 | ARF6 (0.36) | MAPTRXFP1LMNAKDM4EALDH1A1 | |
| SCHEMBL15926361 | 0.82 | HCAR2 (0.35) | MAPTKDM4EALDH1A1GAAGABRA1 | |
| SCHEMBL15908945 | 0.82 | ARF6 (0.45) | MAPTLMNATHRBKDM4EALDH1A1 | |
| SCHEMBL15926359 | 0.80 | KDM4E (0.35) | POLBMAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL1279265 | 0.78 | SMN1; SMN2 (0.41) | RXFP1LMNAKDM4EALDH1A1GAA | |
| SCHEMBL1279212 | 0.78 | ADORA2A (0.35) | POLBMAPTKDM4EALDH1A1GAA | |
| SCHEMBL1278649 | 0.78 | KDM4E (0.39) | POLBMAPTRXFP1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |