Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 13/20 | 0.41 |
| ▸ | MAPT | P10636 | 11/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ARF6 | P62330 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15909266 | 0.87 | ARF6 (0.39) | MAPTLMNAARF6TDP1 | |
| SCHEMBL1615068 | 0.85 | MAPK14 (0.37) | POLBMAPTMAPK14LMNAARF6 | |
| SCHEMBL15909113 | 0.84 | POLB (0.36) | POLBMAPTRXFP1LMNATHRB | |
| SCHEMBL15926321 | 0.84 | MAPK14 (0.40) | POLBMAPTMAPK14RXFP1LMNA | |
| SCHEMBL1279271 | 0.83 | MAPK14 (0.41) | POLBMAPTMAPK14RXFP1LMNA | |
| SCHEMBL1279158 | 0.80 | ADORA3 (0.39) | POLBMAPTMAPK14ARF6GRIN1 | |
| SCHEMBL15909132 | 0.76 | ARF6 (0.36) | MAPTLMNAARF6 | |
| SCHEMBL1614861 | 0.74 | ARF6 (0.39) | MAPTARF6TDP1 | |
| SCHEMBL1614869 | 0.72 | MAPT (0.38) | POLBMAPTLMNATHRBTDP1 | |
| SCHEMBL15908924 | 0.72 | ARF6 (0.42) | POLBLMNAARF6L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |