Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962543 | 1.00 | TSHR (0.53) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL4583425 | 0.86 | TSHR (0.57) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL357344 | 0.78 | CA1 (0.52) | CES2CES1ACHETDP1 | |
| SCHEMBL4203388 | 0.77 | TSHR (0.67) | TSHRLMNAALDH1A1ALOX15F2 | |
| Dinitrophenylene SCHEMBL28185765 | 0.76 | TSHR (0.71) | TSHRLMNAALDH1A1ALOX15CES2 | |
| SCHEMBL30043252 | 0.76 | TSHR (0.64) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL6273333 | 0.76 | TSHR (0.64) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL2955782 | 0.75 | F2 (0.63) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL7929197 | 0.75 | F2 (0.63) | TSHRLMNAALDH1A1ALOX15F2 | |
| SCHEMBL29045097 | 0.75 | HSPB1 (0.39) | TSHRLMNAALDH1A1ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345636-B1 | CASR AGONIST | AJINOMOTO KK (JP) | 2016-03-30 | — | — | EP | disclosed |
| US-8796485-B2 | CaSR agonists | AJINOMOTO CO., INC. (JP) | 2014-08-05 | — | — | US | disclosed |