SCHEMBL357344

SCHEMBL357344

O=[N+]([O-])c1ccc(O[PH](=O)O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
CES1 P23141 2/20 0.52
CES2 O00748 1/20 0.52
HSPB1 P04792 1/20 0.48
GAA P10253 1/20 0.47
CA9 Q16790 1/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 2/20 0.46
NPC1 O15118 1/20 0.46
MAPT P10636 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
MYOC Q99972 1/20 0.46
BCL9 O00512 1/20 0.45
CTNNB1 P35222 1/20 0.45
SRD5A2 P31213 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
PKM P14618 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL357343 0.83 HSPB1 (0.52) CA1CA2CES1CES2HSPB1
SCHEMBL15588700 0.80 HSPB1 (0.48) CA1CA2CES1CES2HSPB1
SCHEMBL30777840 0.80 HSPB1 (0.48) CA1CA2CES1CES2HSPB1
SCHEMBL15849787 0.80 MEN1 (0.30) KMT2AMEN1
SCHEMBL15909498 0.78 TSHR (0.53) CES1CES2TDP1ACHE
SCHEMBL1962543 0.78 TSHR (0.53) CES1CES2TDP1ACHE
SCHEMBL5409494 0.77 ALDH1A1 (0.54) CA1CA2CES1CES2HSPB1
SCHEMBL9466346 0.74 HSPB1 (0.61) CA1CA2CES1CES2HSPB1
4,4'-Oxybis(Nitrobenzene) SCHEMBL134332 0.73 HSPB1 (0.79) CA1CA2CES1CES2HSPB1
SCHEMBL11689190 0.73 HSPB1 (0.79) CA1CA2CES1CES2HSPB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly UNIV NORTHWESTERN (US) 2025-10-23 US claimed
WO-2024025604-A9 DEVELOPMENT OF AN ENZYME-INHIBITOR REACTION USING CELLULAR RETINOIC ACID BINDING PROTEIN II FOR ONE-POT MEGAMOLECULE ASSEMBLY NORTHWESTERN UNIVERSITY (US) 2024-05-02 WO claimed
WO-2024025604-A2 DEVELOPMENT OF AN ENZYME-INHIBITOR REACTION USING CELLULAR RETINOIC ACID BINDING PROTEIN II FOR ONE-POT MEGAMOLECULE ASSEMBLY NORTHWESTERN UNIVERSITY (US) 2024-02-01 WO claimed
CN-110612119-A Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents 西雅图儿童医院(DBA西雅图儿童研究所) 2019-12-24 CN claimed
US-20190161556-A1 Fusion Protein Construct NORTHWESTERN UNIVERSITY 2019-05-30 US claimed
CN-109661407-A Fusion protein constructs 西北大学 2019-04-19 CN claimed
EP-2311939-A1 Polypeptide immobilization The University of Chicago (US) 2011-04-20 EP claimed
US-7888055-B2 Selectively binds with absolute control over orientation and density without requiring prior synthetic modification or purification to make a stable protein chip; rapid and irreversible; assaying kinase or protease activity THE UNIVERSITY OF CHICAGO (US) 2011-02-15 US claimed
WO-2026101423-A1 PHOTOSWITCHABLE CHEMICAL INDUCED DIMERIZATION SYSTEMS FOR CONTROL OF CELLULAR ACTIVITIES WITH LIGHT WU YAOWEN (SE) 2026-05-15 WO disclosed
US-20260063641-A1 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS UNIV UTAH RES FOUND (US) 2026-03-05 US disclosed
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly UNIV NORTHWESTERN (US) 2025-10-23 US disclosed
EP-4565594-A2 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS University of Utah Research Foundation (US) 2025-06-11 EP disclosed
US-20250059301-A1 Fusion Protein Construct NORTHWESTERN UNIVERSITY 2025-02-20 US disclosed
CN-119438107-A Visual detection method for organochlorine pesticide based on metal-organic framework immobilized enzyme composite material 吉林大学 2025-02-14 CN disclosed
WO-1997040141-A2 ISOLATION OF ENZYMES MEDICAL RESEARCH COUNCIL (GB) 1997-10-30 WO disclosed
EP-0362304-B1 CHEMICAL SENSORS EMPLOYING CATALYTIC ANTIBODIES IGEN INC (US) 1997-03-05 EP disclosed
WO-1993012144-A1 ANTIBODY-MEDIATED REDUCTION OF α-KETOAMIDES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1993-06-24 WO disclosed
EP-0362304-A4 CHEMICAL SENSORS EMPLOYING CATALYTIC ANTIBODIES 1991-04-10 EP disclosed
EP-0362304-A1 CHEMICAL SENSORS EMPLOYING CATALYTIC ANTIBODIES. IGEN INC (US) 1990-04-11 EP disclosed
WO-1989005977-A1 CHEMICAL SENSORS EMPLOYING CATALYTIC ANTIBODIES IGEN, INC. (US) 1989-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260063641-A1 COMPOSITIONS AND METHODS FOR LABELING AND DETECTING BINDING PARTNERS ATIC, JMJD7, UCHL1 CA1 4569/4885CA2 4467/4885CES1 399/4885
US-20250059301-A1 Fusion Protein Construct RPS27A, CD2BP2, JMJD7 CA1 1971/4885CA2 2987/4885CES1 926/4885
US-20190161556-A1 Fusion Protein Construct RPS27A, CD2BP2, JMJD7 CA1 1971/4885CA2 2987/4885CES1 926/4885
US-20250326723-A1 Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly CRABP2, RARB, RARA CA1 1293/4885CA2 620/4885CES1 457/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.