Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104802 | 0.79 | DYRK1A (0.45) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL29350099 | 0.69 | NPC1 (0.65) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL150476 | 0.69 | NPC1 (0.65) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL21530593 | 0.68 | KDM4E (0.50) | NPC1RAB9AMAPTKDM4ESMN1; SMN2 | |
| SCHEMBL6647315 | 0.67 | NPC1 (0.62) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL13156510 | 0.65 | NPC1 (0.60) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL18700662 | 0.65 | NPC1 (0.60) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL13156520 | 0.65 | NPC1 (0.60) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL12532559 | 0.65 | NPC1 (0.60) | NPC1POLBRAB9ACASP6ALDH1A1 | |
| SCHEMBL50867 | 0.63 | ALDH1A1 (0.61) | NPC1POLBRAB9ACASP6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796303-B2 | Imidazo[2,1-G][1,7]naphthyridines for treating respiratory syncytial virus infections | BIOTA SCIENTIFIC MANAGEMENT PTY LTD. (AU) | 2014-08-05 | — | — | US | disclosed |